Tantargy

Data

Official data in SubjectManager for the following academic year: 2025-2026

Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the field of pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics, pharmacology of the autonomic nervous system and the cardiovascular system.

Lectures

• 1. Introduction to neuropharmacology. General characterization of the autonomic nervous system - Pozsgai Gábor
• 2. Cholinergic agonists - Pozsgai Gábor
• 3. Cholinesterase inhibitors I - Pozsgai Gábor
• 4. Cholinesterase inhibitors II - Pozsgai Gábor
• 5. Muscarinic receptor antagonists I - Pozsgai Gábor
• 6. Muscarinic receptor antagonists II - Pozsgai Gábor
• 7. Neuromuscular blocking agents I - Pethő Gábor István
• 8. Neuromuscular blocking agents II - Pethő Gábor István
• 9. Agents acting on biosynthesis, storage, release and elimination of catecholamines I - Pethő Gábor István
• 10. Agents acting on biosynthesis, storage, release and elimination of catecholamines II - Pethő Gábor István
• 11. Adrenergic receptor agonists I - Pethő Gábor István
• 12. Adrenergic receptor agonists II - Pethő Gábor István
• 13. Adrenergic receptor antagonists I - Pethő Gábor István
• 14. Adrenergic receptor antagonists II - Pethő Gábor István
• 15.

  Pharmacology of the calcium channels I

  - Göntér Kitti
• 16.

  Pharmacology of the calcium channels II

  - Göntér Kitti
• 17. Drugs acting on the renin-angiotensin-aldosterone system I - Kriszta Gábor
• 18. Drugs acting on the renin-angiotensin-aldosterone system II - Kriszta Gábor
• 19. Diuretic drugs I - Pethő Gábor István
• 20. Diuretic drugs II - Pethő Gábor István
• 21. Drugs used for treating congestive heart failure I - Kriszta Gábor
• 22. Drugs used for treating congestive heart failure II - Kriszta Gábor
• 23. Antiarrhythmic drugs I - Pethő Gábor István
• 24. Antiarrhythmic drugs II - Pethő Gábor István
• 25. Antianginal drugs I - Pozsgai Gábor
• 26. Antianginal drugs II. Drugs increasing regional blood flow - Pozsgai Gábor
• 27. Antihypertensive drugs I - Pethő Gábor István
• 28. Antihypertensive drugs II - Pethő Gábor István

Practices

Seminars

• 1. Introduction to pharmacodynamics I - Pethő Gábor István
• 2. Introduction to pharmacodynamics II - Pethő Gábor István
• 3. Basic mechanisms of drug actions - Fliszár-Nyúl Eszter
• 4. Characterization of the agonist-receptor interaction I - Fliszár-Nyúl Eszter
• 5. Characterization of the agonist-receptor interaction II - Fliszár-Nyúl Eszter
• 6. Characterization of the agonist-receptor interaction III - Fliszár-Nyúl Eszter
• 7. Signal transduction mechanisms of drug receptors - Hartnerné Pohóczky Krisztina
• 8. Tachyphylaxis and tolerance - Hartnerné Pohóczky Krisztina
• 9. Mechanisms of drug antagonisms I - Hartnerné Pohóczky Krisztina
• 10. Mechanisms of drug antagonisms II - Hartnerné Pohóczky Krisztina
• 11.

  Transport of drugs across membranes

  - Göntér Kitti
• 12. Absorption of drugs I - Kriszta Gábor
• 13. Absorption of drugs II - Kriszta Gábor
• 14. Distribution of drugs - Kriszta Gábor
• 15. Biotransformation of drugs I - Fliszár-Nyúl Eszter
• 16. Biotransformation of drugs II - Fliszár-Nyúl Eszter
• 17. Excretion of drugs I - Pozsgai Gábor
• 18. Excretion of drugs II - Pozsgai Gábor
• 19.

  Pharmacokinetic parameters I

  - Göntér Kitti
• 20.

  Pharmacokinetic parameters II

  - Göntér Kitti
• 21.

  Pharmacokinetic parameters III

  - Göntér Kitti
• 22. Local anesthetics I - Pethő Gábor István
• 23. Local anesthetics II - Pethő Gábor István
• 24. Theoretical basis of the modulation of the pharmacology of the autonomic nervous system. Drugs acting on autonomic ganglia - Pethő Gábor István
• 25.

  Analysis of the effects of drugs acting on the autonomic nervous system using computer simulation I

  - Nagy András
• 26.

  Analysis of the effects of drugs acting on the autonomic nervous system using computer simulation II

  - Nagy András
• 27. Discussion of the pharmacology of the autonomic nervous system I - Pozsgai Gábor
• 28. Discussion of the pharmacology of the autonomic nervous system II - Pozsgai Gábor

Reading material

Obligatory literature

Literature developed by the Department

Electronic handouts are provided for most topics.

Notes

Recommended literature

Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2019

B. G. Katzung (ed.): Basic and Clinical Pharmacology, 14th edition, Lange Medical Books/McGraw-Hill, 2018

Conditions for acceptance of the semester

Required 50% performance on the midterm exam. Make up is possible until the end of the semester period if needed.

Mid-term exams

Midterm exam might be group work or written test.

Making up for missed classes

There is no way to make up for missed classes.

Exam topics/questions

Reqirements: the exams are oral, the required topics are dealt with during the semester lectures and practical classes. The criterion of admission to the exam is the successful completion of the Pharmacodynamics 1 practice course carried out in paralell (at least satisfactory midsemester grade).

Exam questions:

1. Basic mechanisms of drug actions

2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy

3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs

4. Mechanisms of drug antagonisms

5. Transport of drugs across membranes

6. Absorption of drugs, oral bioavailability and presystemic elimination

7. Distribution of drugs

8. Biotransformation of drugs

9. Excretion of drugs

10. Quantitative pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability, calculation of loading and maintenance doses, non-linear pharmacokinetics

11. Cholinergic agonists and cholinesterase inhibitors

12. Muscarinic receptor antagonists

13. Neuromuscular blocking agents. Drugs acting on autonomic ganglia

14. Agents acting on the biosynthesis, storage, release and elimination of catecholamines

15. Adrenergic receptor agonists

16. Adrenergic receptor antagonists

17. Local anesthetics

18. Calcium channel blockers

19. Drugs acting on the renin-angiotensin-aldosterone system

20. Diuretic drugs

21. Positive inotropic and other drugs used to treat congestive heart failure

22. Antianginal drugs. Drugs that increase regional blood flow

23. Antihypertensive drugs

24. Antiarrhythmic drug

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the student.

Examiners

• Fliszár-Nyúl Eszter
• Kriszta Gábor
• Pethő Gábor István
• Pozsgai Gábor

Instructor / tutor of practices and seminars

• Fliszár-Nyúl Eszter
• Göntér Kitti
• Hartnerné Pohóczky Krisztina
• Kriszta Gábor
• Nagy András
• Pethő Gábor István
• Pozsgai Gábor