Data
Official data in SubjectManager for the following academic year: 2024-2025
Course director
Kovács Barna Szilárd
associate professor,
Institute of Pharmaceutical Technology and Biopharmacy
Number of hours/semester
Lectures: 28 hours
Practices: 0 hours
Seminars: 0 hours
Total of: 28 hours
Subject data
- Code of subject: OPF-OPS-T
- 2 Credit
- Pharmacy
- Optional module
- spring
OPA-PC1-T finished
Course headcount limitations
min. 5 people – max. 15 people
Topic
Optical sensors are widely used for in-situ, in vivo and online measurements as well as in process control. The interaction of light with materials results in a broad range of possible optical sensing methods. The selective chemical recognition coupled with optical detection techniques allow to create optical sensors with completely different geometry. Students taking the course will learn the different kind of optical sensors, their working principles; medical applications, the applications in environmental monitoring and process control are also discussed.
Lectures
- 1.
Interaction of electromagnetic waves and matter
- Kovács Barna Szilárd - 2.
Optical properties and their measurement with conventional laboratory equipment
- Kovács Barna Szilárd - 3.
Spectroscopic setup used for sensor application
- Kovács Barna Szilárd - 4.
Absorption, refractive index and fluorescence measurements in optical sensors
- Kovács Barna Szilárd - 5.
Measurement of mechanical and electric parameters via optical sensors
- Kovács Barna Szilárd - 6.
Major components of optical sensors
- Kovács Barna Szilárd - 7.
Optical parts; build-up of optodes
- Kovács Barna Szilárd - 8.
Immobilization of indicators: covalent bond, lipophilic indicators
- Kovács Barna Szilárd - 9.
Adsorption, sol-gel method, ion-pairing
- Kovács Barna Szilárd - 10.
Group work
- Kovács Barna Szilárd - 11.
Group work
- Kovács Barna Szilárd - 12.
Nano beads and quantum dots (QDs) in optical sensors
- Kovács Barna Szilárd - 13.
Polymers, polymer layers
- Kovács Barna Szilárd - 14.
The role of additives on the membrane stability
- Kovács Barna Szilárd - 15.
Optical isolation, primary- and preventive layers
- Kovács Barna Szilárd - 16.
Configurations of optodes: optical fibers, waveguides, capillaries, nanobeads
- Kovács Barna Szilárd - 17.
Optical sensors for pH and ion concentration measurements
- Kovács Barna Szilárd - 18.
Co-extraction and ion-exchange mechanisms
- Kovács Barna Szilárd - 19.
Optical gas sensing in everyday use
- Kovács Barna Szilárd - 20.
Group work
- Kovács Barna Szilárd - 21.
Group work
- Kovács Barna Szilárd - 22.
Optical sensors in medical diagnostics
- Kovács Barna Szilárd - 23.
Measurements in living cells
- Kovács Barna Szilárd - 24.
Optical biosensors I: biocatalytic sensors (enzymes, bacteria)
- Kovács Barna Szilárd - 25.
Optical biosensors II: Receptor based sensors, and immuno-complex based sensing. DNA fragment based sensors, aptamer sensing, MIPs
- Kovács Barna Szilárd - 26.
Group work
- Kovács Barna Szilárd - 27.
Group work
- Kovács Barna Szilárd - 28.
Summary, test
- Kovács Barna Szilárd
Practices
Seminars
Reading material
Obligatory literature
Optical Chemical Sensors (ed. F. Baldini, A.N. Chester, J. Homola, S. Martellucci), NATO Science Series II. Vol 224, Springer, 2006
R.W. Cattrall: Chemical Sensors, Oxford Science, 1997
B.R. Eggins: Biosensors: an Introduction, Wiley, 1996
Literature developed by the Department
Notes
Recommended literature
Conditions for acceptance of the semester
Participating in the project groupwork, grade of the written test
Mid-term exams
Oral, during the project groupwork
Making up for missed classes
By arrangement with the lecturer
Exam topics/questions
-
Examiners
- Kovács Barna Szilárd