Our TDK topics
Determination of logP value of chalcone- and curcuminoid derivatives.
Supervisor: ROZMER, Zsuzsanna
Co-Supervisor: Dr. TYUKODI, Levente
Development of analytical methods to determine drugs and drug metabolites.
Supervisor: PERJÉSI, Pál
In the course of the work, students will get acquainted with the chemical basics of drug metabolism and will be involved in the development or application of an analytical method for the determination of a drug compound and its metabolites.
Examination of different plant extracts by instrumental analytical methods
Supervisor: KULCSÁR, Győző
Co-Supervisor: Dr. TYUKODI, Levente
The aim of the research is to investigate the active compound content of extracts made from various plant parts, with a focus on bioactive compounds such as cannabinoids or antioxidants. During the research, analytical methods (e.g., HPLC, GC-MS, LC-MS) will be used to identify and quantify the composition of the extracts.
In vivo and in vitro non-enzymatic and enzymatic oxidation of phenolic compounds
Supervisor: ALMÁSI, Attila
Interaction of curcuminoids and chalcone analogues with cellular macromolecules.
Supervisor: ROZMER, Zsuzsanna
Co-Supervisor: Dr. TYUKODI, Levente
Investigation of permeability of chalcone- and curcuminoid derivatives
Supervisor: ROZMER, Zsuzsanna
Co-Supervisor: Dr. TYUKODI, Levente
Stereochemical study of biologically relevant reactions of chalcones and chalcone analogues
Supervisor: PERJÉSI, Pál
In the course of the work, the students get acquainted with the most important chemical reactions of chalcones and study the stereochemistry of the reactions of differently substituted derivatives using the example of a selected reaction.
Structure-activity relationships of reactions of chalcones and cylic chalcone analogues
Supervisor: PERJÉSI, Pál
In the course of the work, students get acquainted with the most important chemical reactions of chalcones and study the relationships of the chemical reactivity-biological effect of differently substituted derivatives using the example of a relevant reaction.
Study on kinetic and stereochemical aspects of GSH-conjugation reaction of chalcones and cyclic chalcone analogues.
Supervisor: PERJÉSI, Pál
In this work, students will learn about the mechanism of glutathione (GSH) conjugation reactions and study the kinetics and stereochemistry of spontaneous and enzyme-catalyzed reactions of compounds using the examples of some chalcone derivatives.
Study on the effect of curcuminoid derivatives on enzyme activity
Supervisor: ROZMER, Zsuzsanna
Co-Supervisor: Dr. KOVÁCS-ROZMER, Katalin
Study on the effect of curcuminoid derivatives ont he cell-cycle
Supervisor: ROZMER, Zsuzsanna
Co-Supervisor: Dr. FÜLÖPNÉ KISS, Edit
Transportmechanisms and metabolism of drug molecules in the small intestine. Structure-activity relationships.
Supervisor: ALMÁSI, Attila
Co-Supervisor: Dr. MÉSZÁROS, Petra