Data
Official data in SubjectManager for the following academic year: 2024-2025
Course director
Rozmer Zsuzsanna
associate professor,
Department of Paediatrics
Number of hours/semester
Lectures: 28 hours
Practices: 0 hours
Seminars: 0 hours
Total of: 28 hours
Subject data
- Code of subject: OPE-GFK-T
- 2 Credit
- Pharmacy
- Elective module
- spring
Prerequisites:
haven't
Course headcount limitations
min. 3 people – max. 20 people
Topic
The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets for better understanding the drug action.
Lectures
- 1. Molecular bases of biological actions. Structural characteristics of drug targets. - Rozmer Zsuzsanna
- 2. Molecular bases of biological actions. Structural characteristics of drug targets. - Rozmer Zsuzsanna
- 3. Receptors as drug targets. - Rozmer Zsuzsanna
- 4. Receptors as drug targets. - Rozmer Zsuzsanna
- 5. Enzymes as drug targets. - Rozmer Zsuzsanna
- 6. Enzymes as drug targets. - Rozmer Zsuzsanna
- 7. Transporters and ion channels as drug targets. - Rozmer Zsuzsanna
- 8. Transporters and ion channels as drug targets. - Rozmer Zsuzsanna
- 9. Nucleic acids as drug targets. - Rozmer Zsuzsanna
- 10. Nucleic acids as drug targets. - Rozmer Zsuzsanna
- 11. Physicochemical properties of drug-drug target interactions. Intermolecular bonding. - Rozmer Zsuzsanna
- 12. Physicochemical properties of drug-drug target interactions. Intermolecular bonding. - Rozmer Zsuzsanna
- 13. Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity. - Rozmer Zsuzsanna
- 14. Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity. - Rozmer Zsuzsanna
- 15. Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry. - Rozmer Zsuzsanna
- 16. Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry. - Rozmer Zsuzsanna
- 17. Physicochemical characteristics of drugs. Solubility. - Rozmer Zsuzsanna
- 18. Physicochemical characteristics of drugs. Solubility. - Rozmer Zsuzsanna
- 19. Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value. - Rozmer Zsuzsanna
- 20. Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value. - Rozmer Zsuzsanna
- 21. Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients. - Rozmer Zsuzsanna
- 22. Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients. - Rozmer Zsuzsanna
- 23. Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability. - Rozmer Zsuzsanna
- 24. Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability. - Rozmer Zsuzsanna
- 25. In silico ADME modelling. In vitro and in vivo tests. - Rozmer Zsuzsanna
- 26. In silico ADME modelling. In vitro and in vivo tests. - Rozmer Zsuzsanna
- 27. Physicochemical characteristics of drugs. Metabolic stability. - Rozmer Zsuzsanna
- 28. Physicochemical characteristics of drugs. Metabolic stability. - Rozmer Zsuzsanna
Practices
Seminars
Reading material
Obligatory literature
-
Literature developed by the Department
PPT slides of the lectures
Notes
Zsuzsanna Rozmer, Pál Perjési: The physico-chemical bases of drug actions. PTE, 2015.
Recommended literature
-
Conditions for acceptance of the semester
Successful written exam.
Mid-term exams
Written test.
Making up for missed classes
None.
Exam topics/questions
Topics of the written tests are set by the course director.
Examiners
Instructor / tutor of practices and seminars
- Rozmer Zsuzsanna