Student Researchers' Society Topics

Co-Supervisor: Ifj. Dr. KÁSA, Péter

Orodispersible tablets play a great role in life saving situations. Dissolution amd disintegration properties, their investigation and its improvement is essential for the pharmaceutical therapy. This topic aims to reveal the relationship between the manufacturing process parametrs, excipients and the dissolution of the tablets. Within the topic the student has to plan an experimental design, participates in the manufacture and carries out the measurements.

Development of a Co-amorphous Drug-Drug Delivery System

Tablet compression of plant cell containing materials makes production extremely difficult. Usually the higher the natural content in a tablet is, the harder the tablet compression can be carried out. The aim of this topic is to optimize a tablet’s ingredients by maximizing the natural content, selecting the proper excipients and match the basic criteria of tablets.

Co-Supervisor: Dr. PÁL, Szilárd

This scientific topic includes the preformulation studies of the glutaminic acid, tablet compression and examination of the prepared tablets. Preparation will be carried out according to an experimental design, then after evaluation, an optimized composition and tableting process parameters will be re-adjusted in order to maximize tablet's mechanical properties.

The research topic focuses on utilizing computational tools and experimental techniques to identify and validate promising cocrystals for pharmaceutical applications. Cocrystallization offers a powerful approach to enhancing the physicochemical properties of drugs, such as solubility, stability, and bioavailability. However, selecting the right coformers for cocrystallization remains a significant challenge.

This research aims to explore whether virtual screening using the Cambridge Structural Database (CSD) can effectively identify potential coformers for a specific pharmaceutical or class of pharmaceuticals. By employing CSD's extensive database, researchers will screen for coformers based on structural similarity, molecular properties, and other relevant criteria. The identified coformers will then serve as candidates for experimental validation.

In the experimental phase, various cocrystallization techniques, including solvent evaporation, melt quenching, and grinding, will be used to synthesize the predicted cocrystals. The formation and structural integrity of these cocrystals will be confirmed using techniques like X-ray diffraction, thermal analysis, and spectroscopy. These methods will also help in characterizing the physicochemical properties of the cocrystals, such as solubility, stability, and bioavailability.

The research will compare the properties of the cocrystals with the pure drug, assessing the potential advantages of cocrystallization, such as enhanced drug performance and therapeutic efficacy. This study aims to demonstrate the effectiveness of virtual screening using the CSD in predicting successful cocrystal formations, contributing to the development of optimized drug formulations through rational design.

Production of food supplements is very close to operations and procedures used in pharmaceutical technology. It can be observed, that tablets and capsules containing food supplements are actually made by the same way, and using the same methods as in pharmaceutics. Aim of this topic is to focus on production and examination of solid dosage forms containing food supplements, comparing their quality to medicines of the same category, carrying out main pharmaceutical technological investigations independently from the active ingredients.

Development and characterization of natural product-based semisolid formulation for pharmaceutical application: Design, Evaluation and In-Vitro assessments.

Pharmaceutical residues in water systems, including wastewater, rivers, lakes, and drinking water, present a growing environmental and public health challenge. This research investigates the application of carbon nanostructures, such as carbon nanotubes and graphene-based materials, for pharmaceutical residue removal, focusing on their adsorption efficiency, long-term stability, and environmental impact. The study will compare functionalized and non-functionalized nanomaterials and explore their regeneration potential over multiple adsorption-desorption cycles. Additionally, it will assess the effectiveness of household drinking water filters, such as water pitcher filters, in reducing pharmaceutical contaminants. The research will evaluate environmental risks associated with nanomaterials in water treatment, weighing the benefits of pharmaceutical residue removal against potential hazards.

Tablet compression of herb derived materials is a great challenge, since herb derived substances and plant cells usually have highly elastic properties, which makes it extremely difficult to produce tablets with acceptable physical properties. Aim of this topic is to acquire knowledge in this field, including testing compressibility properties of various plant derived materials.

Co-Supervisor: Dr. PÁL, Szilárd

This scientific research project aims the pharmaceutical technological formulation of finely pulverized grape seed in order to produce a dietary supplement in form of a tablet. Topic include preformulation studies, the production itself and the examination of the preparation.

The research topic explores the interactions between naturally derived bioactive compounds and plasma proteins. Bioactive compounds from medicinal plants, long used in traditional medicine, have garnered significant interest as potential alternatives to synthetic chemicals due to their antibacterial, anticancer, and anti-inflammatory properties. While these therapeutic effects have been validated, the physiological functions and interactions of these compounds with cells and proteins remain underexplored.

This research will focus on investigating the binding of naturally derived bioactive compounds to plasma proteins using spectroscopic, chromatographic, electrochemical, microscopic and particle characterization methods. Special attention will be given to albumin binding and the application of albumin nanoparticles as drug carrier systems, as the affinity between bioactive compounds and albumin plays a crucial role in the effective design of nanoparticles. The study will also consider the interactions of these compounds with other plasma proteins to provide a broader understanding of their behavior in biological systems. By examining these interactions, the research aims to enhance the stability of bioactive compounds through albumin-based nanocarriers and contribute to the development of more efficient drug delivery systems.